Over the past decade, Artificial Intelligence (AI) has made stunning advances, from mastering language to solving the structure of proteins. These breakthroughs arise from more than forty years of work in neural networks, where ideas from neuroscience have inspired solutions in AI. In this lecture, Anthony Zador, MD, PhD, will explore how reverse engineering the brain’s computations has driven progress in both fields, and how this back-and-forth between neuroscience and AI is set to grow even stronger — with brain-inspired designs driving new AI advances while AI tools transform our understanding of how the brain works.